Predictive Sensory Evaluation · Hans-Made Research Inc.

Know the taste
before you make
the molecule.

Predictive Sensory Evaluation — a molecule's taste, off-notes and blend behaviour, predicted from its structure before the sample exists. Deterministic, zero training data, correlated against a University of Manitoba lab. It does not replace a tasting panel; it tells you what to put in front of one.

▶ The full pitch deck See the proof The ask
R² 0.95e-tongue · U of M lab
89%bitter blind (held-out)
0training rows
secondson a laptop
🐝 the roadmap →
The problem

Off-flavour is the wall plant protein keeps hitting.

Bitterness is expensive enough to close a plant.

Merit Functional Foods — the only commercial food-grade canola-protein plant in the world — was sold off in 2025. Today the off-note is hunted the slow way: chromatography and trained tasting panels. Enzyme fixes cut hydrolysate bitterness by about half. And flavour is collective — you cannot predict a blend by summing its parts. You find out after you've already made it.

Why now

Manitoba bet $1.4 billion on plant protein. Taste is what's left to solve.

Roquette runs the world's largest pea-protein plant in Portage la Prairie; Protein Industries Canada is funding blended-protein products; the grid is 99% renewable. The off-notes — beany, bitter, astringent — gate the entire sector, and they're still found by hand. "Manitoba can be the Silicon Valley of plant protein." — Roquette

What it covers

The whole sensory panel — computed from structure.

One structure in — a SMILES string or a peptide sequence — and the full sensory read comes back in seconds.

Taste & off-note

Bitter or astringent, sweet or umami — modality and all — plus the green, beany or rancid aromas, before anything is made.

Mixtures & palatability

The collective, non-additive palatability of a whole blend — and a search across partners and ratios for the most palatable combination.

Who tastes it

Genetic taste variation — how a supertaster and a non-taster read the same compound, modelled at the receptor level.

Masking

A matched counter-profile where the off-note is unavoidable — ranked, compound-specific maskers, not guesswork.

Control

The enzyme, process or storage change that stops the off-note forming in the first place.

Safety & stability

The same structure also flags safety and stability — a fuller read than a taste panel alone can give.

Why it's different

Not another AI model — the opposite of one.

Codex

✓ Zero training data — nothing to assemble first

✓ Deterministic — same structure, same answer, every time

✓ Names the mechanism behind every call

✓ Reads molecules no one has made yet

✓ Milliseconds on a laptop — no GPU cluster

Typical taste / discovery AI

✕ Needs a large labelled training set

✕ A black-box score — no "why"

✕ Re-train for every new class of chemistry

✕ Struggles exactly where there is no prior data

✕ GPU farms — and curated scores that don't survive the real world

No training corpus to leak or out-scale, and no compute bill to pass on — which is also why we can price below anyone running on GPUs.

Under the hood

One structure in. A platform of engines fires. One verdict out.

This is not a single trained classifier. A molecule enters and the relevant engines run in concert — taste gates, a membrane e-tongue, structural safety vetoes, a mixture lateral-inhibition matrix — each reading the same structure through a different physical lens. The depth is the moat: a rival with more data cannot out-scale a method that needs none.

249computational routes
188modules · ~120 engines
~17 msper compound
Task · industryEngines that fireWhat it returnsBenchmarked
Taste & off-note
food
28-phase taste gate → membrane e-tongue → 23 structural vetoes → intensity cascadebitter / astringent / sweet / umami, with modality & confidenceChemTastesDB 82.9% · MCC 0.68
Mixtures & palatability
food
lateral-inhibition matrix across every pair + dose-responsenon-additive blend palatability + optimal partner & rationon-additivity reproduced
Masking
food
receptor-suppression masker ranking + sequestration model + 4-parameter dose-titrationranked maskers, the named mechanism, predicted % reduction & practical dose~80% on quinine · Nakamura / Breslin
Who tastes it
food
TAS2R38 genotype coupling — supertaster · median · non-tasterhow a genotype reads the same compound15× coupling, receptor-level
Safety & stability
food
structural safety alerts (reactive aldehydes / oxidation) + bioavailability & shelf-stabilityoff-note & stability liability with a named mechanism, dose-awarestructural · dose-aware
Crop defence
agriculture
defence-chemistry sort + resistance-shift mapkeep-&-boost vs manage-downstream, from structuredual-axis

One fixed physical method, a different lens per task — proven first where it pays soonest: the food wall.

The proof

Correlated — against a University of Manitoba lab.

Richardson Centre for Food Technology & Research (U of Manitoba), March 2026. An independent wet-lab measured bitterness on an Alpha MOS ASTREE electronic tongue; Codex predicted it from structure across 20 samples. Predicted vs measured: R² 0.95 (Pearson r 0.97) — above the instrument's own calibration (0.94).
89.2%B1 bitter blind · 94.6% not-bitter specificity (MCC 0.79)
MCC 0.62BitterSweet held-out · sweet (84.9% specificity)
84.8%off-note balanced accuracy · ChemTastesDB, 2,517 compounds live · 76% 6-class, sweet-vs-bitter MCC 0.80
~80%masking · NaCl suppresses quinine, structure-only (Nakamura / Breslin)
R² 0.95RCFTR e-tongue · U of Manitoba wet-lab

Every figure is computed live by running the engine — nothing here is a stored claim.

▶ See all the evidence — simple or detailed The U of Manitoba correlation →

▶ Off-flavour screen — demo ▶ Food-space screen — demo ▶ The pilot pitch — slide by slide

On real Canadian crops

It named the culprits and wrote the fix.

Canola & sunflower. The engine flagged sinapine and chlorogenic acid as the bitter levers — and split the two crops on greening (sunflower browns, canola resists) from structure alone.

The pea + canola blend. Blended for amino-acid balance, it reads bitter — because two bitters saturate one receptor, non-additively. The engine ranked the counter-profile that lifts palatability 0.38 → 0.59 (neohesperidin-DC, a known commercial masker) — a deflavouring recipe with no tasting panel.

And aroma. It ranked the rancid aldehydes by oxidative susceptibility (2,4-decadienal > 2-nonenal) — the beany/rancid notes masking can't fix. Taste, aroma, blends, safety: nine sensory channels, one engine.

The bigger prize — valorization. The off-note is the one thing keeping low-value oilseed and pulse meal — today's animal feed — out of the food aisle. Read it from structure, remove it, and the by-product becomes the product: a circular-economy win on streams Manitoba already produces.

The deeper bind

The off-notes are the plant's own defense.

Canola's bitter sinapates and glucosinolates, the phenolics that brown — these are the very compounds the plant makes to fight disease. So breeders are caught in a three-way bind: breed for yield and disease resistance and the protein turns bitter; breed the bitterness out and the crop loses its defense and leans harder on fungicide.

We read all three from structure — before a seed is planted.

The engine sorts a crop's defense chemistry into what to keep and boost — the defenses that protect the plant without loading the meal with off-notes — and what to manage downstream, the bulk compounds that do double duty as both bitterness and defense. It also flags where a crop is most likely to lose to disease pressure first, so the breeding program and the deflavouring program stop working against each other.

One platform across the whole value chain: the agronomy that grows the crop and the food science that makes it palatable — a map for cleaner-tasting protein and more resilient, lower-spray fields.

Why us

A moat you can't copy by scaling.

Deterministic

Same structure, same answer. It computes the result instead of recalling it — so it works on a molecule no one has made yet.

Explainable

Every call traces to a reason a formulator and a regulator can both follow — not a score defended on faith.

Lean

Seconds on a laptop. No training data, no GPU farm. It kills dead-ends before they reach the bench.

Hard to copy

No training corpus to leak, copy or out-scale — a rival with more data and more compute gets no closer. The advantage is structural.

Falsifiable

We publish the conditions that would prove us wrong, and report our own negative results. That's why the numbers are believable — not just asserted.

The same engine reads a crop's disease defense from the same structures it reads for taste. Proof it's physics, not a food-only trick.

The business case

What the science is worth.

The engine's numbers in plain commercial terms — each computed live on a public benchmark of 2,517 compounds, not a whitepaper.

Taste, before synthesis

Sweet-vs-bitter accuracy at MCC 0.80 across 1,800+ compounds. We call the core taste before a molecule is ever made — removing the trial-and-error that gates early R&D.

Off-notes, caught digitally

~85% balanced accuracy detecting off-notes. We flag the bad flavors before a tasting panel runs — and a single failed flavor reformulation runs $85K–175K and 6–12 months.

The full profile, at scale

76% across six taste classes on the full public database. The same read runs backward — name the target, solve the structure.

Live, not theoretical

2,517 compounds benchmarked in one run, on a laptop. An operational pipeline, ready to ingest commercial data and scale.

Who buys it

Alternative-protein makers first — off-flavour is the #1 barrier to adoption (only ~30% like the average meat-free product vs ~68% for meat). The culprits are hexanal, saponins and polyphenols — exactly what we flag. Then high-protein beverage & bar brands, flavour houses and ingredient majors (Cargill, Ingredion, Roquette).

The market

The slice we sell into — taste modulation / masking — is ~$7.6B today, growing ~7%/yr toward ~$14B, inside a ~$40B flavours & fragrances market. The fastest-growing pain is masking plant-protein off-notes; plant-based launches rose 57% in 2024, most needing it. Every failed flavour cycle runs six figures.

How it's offered

Three blind pilots — send us the lot that's fighting you and pick the read you need: Taste, Product-readiness, or Full dossier. Each is correlated cold against your own data, so a correct call is a real prediction, not a lookup — the path to a partnership.

Why it can't be copied

A rival can train on the same public data and even match the accuracy — that isn't the moat. They still get a black box that breaks on activity cliffs (a tiny structural change flips the taste), re-trains for every new class, fails on molecules no one has made, can't say why, and can't run in reverse to design. Ours is deterministic physics, zero training — the score can't be data leakage (the shuffle-control collapses it to chance), it reads novel chemistry, names the mechanism, and designs backward. They copy the data, not the method — and the method stays ours.

One engine, carried across the food chain

Follow the bee.

A taste pocket is geometry, not an organism — so the same physics that reads one flavour molecule reads the next, across the food chain. Proven on the plate today; the same engine reaches the crop and turns its by-products into food.

🐝
Proven · now

Food

Off-note and masker called from structure. Correlated against the Richardson Centre e-tongue, R² 0.95. Pilots and revenue today.

Next

Crop & defence

The same read sorts a crop's defence chemistry — what to keep and boost vs manage downstream — for palatable protein and lower-spray fields.

The prize

By-product valorization

Turn low-value oilseed and pulse meal — today's animal feed — into food: read the off-note from structure, remove it, and the by-product becomes the product.

The value proposition

Why food first — the same engine, through the fastest door.

A new food ingredient clears in months — at a fraction of the time and cost of the most heavily-regulated industries.

The physics doesn't care which industry it reads — but the regulator does. Clearing a food ingredient (GRAS) takes months and is roughly 1,000× cheaper than the highest-regulation paths. So we prove the engine on the low-regulatory food wall, earn revenue now, and let it fund the harder plays — one engine, staged by regulatory gravity, not scattered across bets.

Improve the ingredient

The taste fixed computationally before it's made — designed out, not masked after.

No black box

Screen five candidates, not fifty — and shuffle the labels and the signal collapses, so it's auditable, not a guess.

Rescue stranded streams

Turn low-value oilseed and pulse meal into food — the by-product becomes the product.

Compress the cycle

De-risk before the bench; the wet lab confirms the shortlist instead of hunting blind.

It's the wedge a data-hungry model can't take: zero training means no corpus to assemble first — so we can start where there is no data, and where the regulatory cost is lowest.

How to engage

The Blind Pilot.

Test the platform's predictive accuracy against your own known data. You provide the SMILES; we return the structural readout — no physical samples required. Because nothing is fit to your compounds, a correct call is a genuine prediction, not a lookup: the cleanest way to prove a zero-training-data method on your own bench.

Tier 1 — Taste Screen. The taste call, the specific off-note culprits, and ranked masking pathways.

Tier 2 — Product Readiness. Tier 1, plus storage stability, solubility, aroma profiling, and shelf-life metrics (oxidative and light).

Tier 3 — Full Commercial Dossier. Tiers 1 and 2, plus precise dosing equivalents, the complete safety stack, bioavailability, and genotype variances.

Funders, advisors, or just curious: a short demonstration on a molecule you choose.

ProcessorsResearchersStudentsPartnersFundersJust curious
Dustin Hansley · Hans-Made Research Inc. · Winnipeg, Manitoba
dustinhansmade@gmail.com · 204-333-0234
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the demos, the U of Manitoba correlation, and the pitch — at codex-resonance.com.